David Duchovny
Dr. Ira Kane
Acting
Julianne Moore
Dr. Allison Reed, CDC
Acting
Orlando Jones
Prof. Harry Phineas Block
Acting
Seann William Scott
Wayne Grey
Acting
Ted Levine
General Russell Woodman
Acting
Ty Burrell
Colonel Flemming
Acting
Ethan Suplee
Deke
Acting
Michael Bower
Danny
Acting
Dan Aykroyd
Governor Lewis
Acting
Gregory Itzin
Cartwright
Acting
Pat Kilbane
Officer Johnson
Acting
Sarah Silverman
Denise
Acting
Michelle Wolff
Carla
Acting
Katharine Towne
Nadine
Acting
Stephanie Hodge
Jill Mason
Acting
John Cho
Student
Acting
Steven Gilborn
Judge Guilder
Acting
Wayne Duvall
Dr. Paulson
Acting
Kyle Gass
Officer Drake
Acting
Jerry Trainor
Tommy
Acting
Jennifer Savidge
Clare
Acting
Wendy Braun
Nurse Tate
Acting
Michael Chapman
Sheriff Long
Camera
Mary Pat Gleason
Customer
Acting
Andrew Bowen
Road Worker
Acting
Chris Wylde
Student
Acting
Tom Woodruff Jr.
Lead Primate Creature (uncredited)
Acting
Ashley Clark
Lt. Cryer
Acting