Catherine O'Hara
Mrs. Frankenstein / Weird Girl / Gym Teacher (voice)
Acting
Martin Short
Mr. Frankenstein / Mr. Burgemeister / Nassor (voice)
Acting
Martin Landau
Mr. Rzykruski (voice)
Acting
Charlie Tahan
Victor Frankenstein (voice)
Acting
Atticus Shaffer
Edgar 'E' Gore (voice)
Acting
Winona Ryder
Elsa Van Helsing (voice)
Acting
Robert Capron
Bob (voice)
Acting
James Hiroyuki Liao
Toshiaki (voice)
Acting
Conchata Ferrell
Bob's Mom (voice)
Acting
Tom Kenny
New Holland Townsfolk (voice)
Acting
Frank Welker
Sparky (voice) (uncredited)
Acting
Dee Bradley Baker
Persephone / Shelly / Were-Rat / Colossus / Mr. Whiskers / Driver (voice) (uncredited)
Acting
Jeff Bennett
Giant Sea Monkeys (voice) (uncredited)
Acting