Roy Scheider

Dr. Heywood Floyd

Acting

John Lithgow

Dr. Walter Curnow

Acting

Helen Mirren

Tanya Kirbuk

Acting

Bob Balaban

Dr. R. Chandra

Acting

Keir Dullea

Dr. David Bowman

Acting

Douglas Rain

HAL 9000 (voice)

Acting

Madolyn Smith Osborne

Caroline Floyd

Acting

Savely Kramarov

Dr. Vladimir Rudenko

Acting

Taliesin Jaffe

Christopher Floyd

Acting

James McEachin

Victor Milson

Acting

Mary Jo Deschanel

Betty Fernandez

Acting

Ilya Baskin

Maxim Brailovsky

Acting

Dana Elcar

Dimitri Moisevitch

Acting

Oleg Rudnik

Dr. Vasili Orlov

Acting

Natasha Shneider

Irina Yakunina

Acting

Vladimir Skomarovsky

Yuri Svetlanov

Acting

Victor Steinbach

Nikolaj Ternovsky

Acting

Candice Bergen

SAL 9000 (voice)

Acting

Gene McGarr

Commercial Announcer

Acting

Herta Ware

Jessie Bowman

Acting

Jan Tříska

Alexander Kovalev

Acting

Larry Carroll

Anchorman on TV

Acting

Cheryl Carter

Nurse

Acting

Ron Recasner

Hospital Neurosurgeon

Acting

Robert Lesser

Dr. Hirsch

Acting

Delana Michaels

Commercial Announcer

Acting

Arthur C. Clarke

Man on Park Bench (uncredited)

Writing