Storm Reid

Meg Murry

Acting

Oprah Winfrey

Mrs. Which

Acting

Reese Witherspoon

Mrs. Whatsit

Acting

Mindy Kaling

Mrs. Who

Acting

Levi Miller

Calvin O'Keefe

Acting

Deric McCabe

Charles Wallace Murry

Acting

Chris Pine

Dr. Alex Murry

Acting

Gugu Mbatha-Raw

Dr. Kate Murry

Acting

Zach Galifianakis

The Happy Medium

Acting

Rowan Blanchard

Veronica Kiley

Acting

Michael Peña

Red

Acting

André Holland

Principal Jenkins

Acting

Bellamy Young

Camazotz Woman

Acting

David Oyelowo

The It (voice)

Acting

Conrad Roberts

Elegant Man

Acting

Lyric Wilson

Young Meg

Acting

Yvette Cason

Mrs. Teacher

Acting

Will McCormack

Mr. Teacher

Acting

Daniel MacPherson

Calvin's Father

Acting

Akemi Look

Air Force Officer

Acting

Tim Kang

School Superintendent

Acting

Michele Norris

Radio News Broadcaster (voice)

Acting

Claire Montwill

Student

Acting

Catelynn Brown

Meg Double

Acting

Ariyah Brown

Meg Double

Acting

Losa Fifita

Meg Double

Acting

Joyce Larkin

Mrs. Who Double

Acting

Teonee Motley

Mrs. Which Double

Acting

Jessica Rockwell

Mrs. Whatsit Double

Acting

Oz Kalvan

Charles Wallace Double

Acting

Isaac Ordonez

Charles Wallace Double

Acting

Kai Miller

Charles Wallace Double

Writing

Leighton Leevard

Charles Wallace Double

Acting

Guillaume Seeleuthner

Charles Wallace Double

Acting

Jacob Eddington

Charles Wallace Double

Acting

Easton Tath

Baby Charles Wallace

Acting

Giselle Paredes

Baby Charles Wallace

Acting

Punnavith Koy

Acting