John Goodman
The Dean (segment "Happy Birthday")
Acting
Sydney Tamiia Poitier
Hannah (segment "Happy Birthday")
Acting
Beverly D'Angelo
Bag Lady (segment "Happy Birthday")
Acting
Christopher Lloyd
Attorney Bum (segment "Happy Birthday")
Acting
David Hyde Pierce
Barney (segment "Happy Birthday")
Acting
Caroline Rhea
Monica (segment "Happy Birthday")
Acting
Jenica Bergere
Sally (segment "Happy Birthday")
Acting
Ken Hudson Campbell
Security Guard (segment "Happy Birthday")
Acting
Roman Danylo
Donald (segment "Happy Birthday")
Acting
Kimiko Gelman
May Lee Ha (segment "Happy Birthday")
Acting
Jean Kasem
Nurse (segment "Happy Birthday")
Acting
Taylor Negron
Policeman (segment "Happy Birthday")
Acting
Travis Wester
Chute Boy (segment "Happy Birthday")
Acting
Dondré Whitfield
Man in Elevator (segment "Happy Birthday")
Acting
Marissa Jaret Winokur
Dean's Secretary (segment "Happy Birthday")
Acting
Bruce Davison
(segment "The Other Side")
Acting
Anthony LaPaglia
Dr. Maas (segment "The Other Side")
Acting
Karen Sillas
Anna (segment "The Other Side")
Acting
Andie MacDowell
Lisa (segment "Reaching Normal")
Acting
Paul Rudd
Kenneth (segment "Reaching Normal")
Acting
Joey Lauren Adams
Sarah (segment "Reaching Normal")
Acting
Alan Rosenberg
Frank (segment "Reaching Normal")
Acting
Joel Grey
Dr. Mensley (segment "Reaching Normal")
Acting
Jolene Blalock
Charlie's Wife (wraparound segments)
Acting
Scott Lowell
Charlie (wraparound segments)
Acting
Stephen Tobolowsky
Tom (wraparound segments)
Acting
Kathleen Wilhoite
Lucy (wraparound segments)
Acting
Ellen DeGeneres
Operator (segment "Reaching Normal") (uncredited)
Acting
Helen Mirren
Distinguished Woman (segment "Happy Birthday") (uncredited)
Acting