Sam Rockwell

Darwin the Guinea Pig (voice)

Acting

Jon Favreau

Hurley the Guinea Pig (voice)

Acting

Tracy Morgan

Blaster the Guinea Pig (voice)

Acting

Penélope Cruz

Juarez the Guinea Pig (voice)

Acting

Nicolas Cage

Speckles the Mole (voice)

Acting

Dee Bradley Baker

Mooch the Fly (voice)

Acting

Bill Nighy

Leonard Saber

Acting

Will Arnett

Kip Killian

Acting

Zach Galifianakis

Ben

Acting

Kelli Garner

Marcie

Acting

Steve Buscemi

Bucky the Hamster (voice)

Acting

Jared Lavette

Jared the Skunk (voice)

Acting

Micah Lavette

Micah the Fox (voice)

Acting

Niecy Nash-Betts

Rosalita

Acting

Loudon Wainwright III

Grandpa Goodman

Acting

Tyler Patrick Jones

Connor

Acting

Piper Mackenzie Harris

Penny

Acting

Chris Ellis

NSA Director

Acting

Gabriel Casseus

Carter

Acting

Justin Mentell

Terrell

Acting

Troy Robinson

Agent

Acting

Travis Davis

Agent

Acting

Corey Michael Eubanks

Agent

Acting

Mini Anden

Saber's Assistant

Acting

Camaron Engels

Skateboarder #1 (as Cameron Engels)

Acting

Steve Kelso

Agent

Crew

Max Favreau

Mice (voice)

Acting

James Huang

Agent

Acting

Jack Conley

Agent Trigstad

Acting