Reese Witherspoon
Susan Murphy / Ginormica (voice)
Acting
Seth Rogen
B.O.B. (voice)
Acting
Hugh Laurie
Dr. Cockroach Ph.D. (voice)
Acting
Rainn Wilson
Gallaxhar (voice)
Acting
Will Arnett
The Missing Link (voice)
Acting
Kiefer Sutherland
General W.R. Monger (voice)
Acting
Paul Rudd
Derek Dietl (voice)
Acting
Stephen Colbert
President Hathaway (voice)
Acting
Julie White
Wendy Murphy (voice)
Acting
Jeffrey Tambor
Carl Murphy (voice)
Acting
Amy Poehler
Computer (voice)
Acting
Ed Helms
News Reporter (voice)
Acting
Renée Zellweger
Katie (voice)
Acting
Sean Bishop
Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice)
Acting
Rich Dietl
Commander / Advisor Smith (voice)
Editing
Rob Letterman
Secret Service Man #1 / Lieutenant (voice)
Directing
Tom McGrath
Wilson (voice)
Acting
Chris Miller
Advisor Cole / Army Commander Jones (voice)
Acting
Mike Mitchell
Advisor Wedgie (voice)
Directing
Kent Osborne
Technician Jerry (voice)
Acting
Latifa Ouaou
Advisor Ouaou / Mrs. Ronson / Female Advisor #2 / Panicked Guest (voice)
Acting
Geoffrey Pomeroy
Soldier #4 / Pilot / Soldier #3 / News Technician (voice)
Acting
David P. Smith
Soldier #1 / Advisor Jackson (voice)
Acting
Lisa Stewart
Bridesmaid Candy (voice)
Production
Conrad Vernon
Advisor Hawk / Advisor Dither / Minister / Secret Service Man #2 / Mama Dietl (voice)
Acting
John Krasinski
Cuthbert (voice)
Acting
Stephen Kearin
Technician Bee (voice)
Acting