Whoopi Goldberg
Ranger Margaret (voice)
Acting
David Spade
Ranger Frank (voice)
Acting
E. G. Daily
Tommy Pickles (voice)
Acting
Tara Strong
Dilan "Dil" Pickles (voice)
Acting
Christine Cavanaugh
Chuckie Finster (voice)
Acting
Kath Soucie
Phil / Lil / Betty DeVille (voices)
Acting
Cheryl Chase
Angelica Pickles (voice)
Acting
Tim Curry
Rex Pester (voice)
Acting
Jack Riley
Stuart 'Stu' Pickles (voice)
Acting
Busta Rhymes
Reptar Wagon (voice)
Acting
Michael Bell
Charles 'Chaz' Finster Sr. / Grandpa Boris Kropotkin / Drew Pickles (voice)
Acting
Joe Alaskey
Grandpa Lou Pickles (voice)
Acting
Phil Proctor
Howard DeVille / Igor (voice)
Acting
Cree Summer
Susie Carmichael (voice)
Acting
Tress MacNeille
Charlotte Pickles (voice)
Acting
Melanie Chartoff
Didi Pickles / Minka Kropotkin (voice)
Acting
Hattie Winston
Lucy Carmichael (voice)
Acting
Andrea Martin
Aunt Miriam (voice)
Acting
Tony Jay
Dr. Lipschitz (voice)
Acting
Abraham Benrubi
Serge (voice)
Acting
Gregg Berger
TV Announcer (voice)
Acting
Charlie Adler
United Express Driver (voice)
Acting
Mary Gross
Female Guest (voice)
Acting
Edie McClurg
Nurse (voice)
Acting
Roger Clinton, Jr.
Air Crewman (voice)
Acting
Margaret Cho
Lt. Klavin (voice)
Acting
Iggy Pop
Newborn Baby (singing voice)
Acting
Louis Fresse
Newborn Baby (singing voice)
Acting
Lisa Loeb
Newborn Baby (singing voice)
Acting
Lenny Kravitz
Newborn Baby (singing voice)
Acting
Dawn Robinson
Newborn Baby (singing voice)
Acting
Lou Rawls
Newborn Baby (singing voice)
Acting
Kate Pierson
Newborn Baby (singing voice)
Acting
Cindy Wilson
Newborn Baby (singing voice)
Acting
Gordon Gano
Newborn Baby (singing voice)
Acting
Laurie Anderson
Newborn Baby (singing voice)
Acting
Malik Isaac Taylor
Newborn Baby (singing voice)
Acting
Fred Schneider
Newborn Baby (singing voice)
Acting
Jakob Dylan
Newborn Baby (singing voice)
Acting
Patti Smith
Newborn Baby (singing voice)
Acting
Beck
Newborn Baby (singing voice)
Acting
Steve Zirnkilton
Reporter (voice)
Acting
Frank Welker
Spike / Monkeys / Scar Snout (voice) (uncredited)
Acting
Phife Dawg
Newborn Baby (Singing Voice)
Acting