John Cusack
Igor (voice)
Acting
Myleene Klass
Dr. Holzwurm (voice)
Acting
Robin Walsh
Dr. Holzwurm's Igor (voice)
Acting
Matt McKenna
Dr. Herzschlag (voice)
Acting
John Cleese
Dr. Glickenstein (voice)
Acting
Steve Buscemi
Scamper (voice)
Acting
Sean Hayes
Brain (voice)
Acting
Eddie Izzard
Dr. Schadenfreude (voice)
Acting
Jay Leno
King Malbert (voice)
Acting
Jennifer Coolidge
Jaclyn / Heidi (voice)
Acting
Molly Shannon
Eva (voice)
Acting
James Lipton
Himself
Acting
Christian Slater
Dr. Schadenfreude's Igor (voice)
Acting
Arsenio Hall
Carl Cristall (voice)
Acting
Jess Harnell
Announcer / Royal Guard #2 (voice)
Acting
Zoë Bright
Blind Woman / Killiseum Fan #1 (voice)
Acting
Sophia Eraklis
Blind Orphan #1 (voice)
Acting
A. Cheron Hall
Blind Orphan #2 / Blind Orphan #4 (voice)
Acting
Alexander Leondis
Blind Orphan #3 (voice)
Acting
Michael Leondis
Blind Orphan #6 (voice)
Acting
Nicole Leondis
Blind Orphan #7 (voice)
Acting
Juliana Leondis
Blind Orphan #5 (voice)
Acting
Robin Tisserand
Blind Orphan #8 (voice)
Acting
Paul Vogt
Buzz Offmann (voice)
Acting
Frank Welker
Animals' vocal effects (voice) (uncredited)
Acting