Debi Derryberry
James Isaac 'Jimmy' Neutron / Nissa (voice)
Acting
Megan Cavanagh
Judy Neutron / Vox (voice)
Acting
Mark DeCarlo
Hugh Neutron / Yokian Waiter (voice)
Acting
Rob Paulsen
Carl Wheezer / Principal Willoughby / Butch / Yokian (voice)
Acting
Jeffrey Garcia
Sheen Estevez (voice)
Acting
Carolyn Lawrence
Cindy Vortex (voice)
Acting
Crystal Scales
Libby Fallfax (voice)
Acting
Andrea Martin
Miss Fowl (voice)
Acting
Candi Milo
Nick Dean / Woman #1 (voice)
Acting
Billy West
Sam / Benny / Man #1 (voice)
Acting
S. Scott Bullock
King Goobot / Yokian / Man #2 / Alarm (voice)
Acting
Paul Greenberg
Ooblar / Yokian Waiter (voice)
Acting
Frank Welker
Goddard / Poultra (voice)
Acting