Chris Rock
Osmosis Jones (voice)
Acting
Laurence Fishburne
Thrax (voice)
Acting
David Hyde Pierce
Drix (voice)
Acting
Brandy Norwood
Leah (voice)
Acting
Bill Murray
Frank Detorre
Acting
Molly Shannon
Mrs. Boyd
Acting
William Shatner
Mayor Phlegmming (voice)
Acting
Ron Howard
Tom Colonic (voice)
Directing
Sherry Lynn
(voice)
Acting
Mickie McGowan
Additional Character Voice (voice)
Acting
Chris Elliott
Bob
Acting
Elena Franklin
Shane Detorre
Acting
Kid Rock
Kidney Rock
Acting
Uncle Kracker
Kidney Rock (voice)
Acting
Carlos Alazraqui
Additional Character Voices (voice)
Acting
Rodger Bumpass
Additional Character Voices (voice)
Acting
Richard Steven Horvitz
Additional Character Voices (voice)
Acting
Danny Mann
Additional Character Voices (voice)
Acting
Mickie McGowan
Additional Character Voices (voice)
Acting
Jonathan Adams
Additional Character Voices (voice)
Acting